Abstract: It is always challenging to guarantee transport time for the organization of cargo express train transporta-tion.Thus,an optimization model of cargo express train organization is proposed in the present study.In view of impact factors of express train transportation organization,a Bi-objective function is introduced for goal description as maximum capacity of cargo handling and minimum time to organize Inter-Bureau express train.IBM ILOG Cplex software is called from C# to derive accurate solution to Pareto solution set.The Jing-jin-ji cargo express train organization is further in-vestigated as a case study.In comparison with the actual operation schedule,the model results show that stop time of Jing-jin-ji cargo express train is effectively shortened under the premise of cargo loading requirements when Pareto solu-tion is 0.50 and 0.51,respectively.The express train X481 and X492 are respectively ahead of the schedule by 127.21 min and 200 min,w hich verifies the effectiveness of the proposed model.Suggestions are also provided to improve opera-tions of the relevant organizations.